Effects of mutations to RBP of Nipah Malaysia on escape from mAbs, cell entry, and Bat EphrinB3 affinity as measured in pseudotyped lentiviral deep mutational scanning experiments

This is is an interactive chart. Mouseover points for details and measurements, and use the top zoom bar to zoom in on specific sites. The options at the bottom let you only show escape for sites with some minimal functional effect, choose the site summary metric, or floor the escape at zero.

The line plots at top show the escape at each site across all sera and for individual sera, and the heatmaps show the effects of individual mutations on sera escape or functions of the protein.

Analysis by Brendan Larsen, Teagan McMahon, and Jesse Bloom (2023).

See https://github.com/dms-vep/Nipah_Malaysia_RBP_DMS for code/data.